Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
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Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD-associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD. Systemically injected AβOs faile...
متن کاملAlzheimer-associated Ab oligomers impact the central nervous system to induce peripheral metabolic deregulation
Alzheimer’s disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD-associated Ab oligomers (AbOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD. Systemically injected AbOs faile...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2015
ISSN: 1757-4676,1757-4684
DOI: 10.15252/emmm.201404183